Assessment of Protective Immunity and Protective Capacity of Hepatitis B Virus Vaccine for Children Living in Different Regions of Jordan

ملخص البحث

Hepatitis B vaccine has been integrated into the current childhood immunization program in Jordan since 1995. Since that date, no studies were made for HBV vaccine assessment on Jordanian children. Main objective in our study is to evaluate the protective immunity levels induced by HBV vaccination among a school entry age group. Risk factors to hepatitis B infection were investigated and the protective capacity of the vaccine was studied. Blood samples were obtained from the study group, ELISA tests performed for all cases for anti-HBsAg, anti-HBcAg, and HBsAg. PCR performed for subjects that exposed to different risk factors. No hepatitis B virus was detected in all the blood samples, where all of them were negative to HBcAb, and the group of risk factors has negative results of HBV DNA and HBsAg. The response to HBV vaccine (Anti-HBsAg) values were classified according to child gender (sex), age and several risk factors in order to investigate any effect of each factor on the values of the Anti-HBsAg, after giving the vaccine. 78.9% of children at school entry age had more than 10 (>10 mIU/ml) of anti-HBsAg, so most children were protected from HBV infection, and this result agree with recent studies. 35.4% of the study children were exposed to different risk factors, which increase the probability of HBV infections. Presence of sub-protecting immunity suggests giving a booster dose at the age of school entry, to prolong and increase the protection immunity of school children. The levels of anti-HBsAg decrease with increase age and the immunity against HBV infection will be decreased too. The infection rate and vaccine response of HBV in both sex were almost the same.

مكان النشر:

J. of Appl. Med. and Bio. Res، العدد Vol 1 (2).

تاريخ البحث:

2016

الكلمات الدلالية:

HBV, vaccine, protecting immunity, Jordan, anti-HBsAg.

ملفات: